Ornithine alpha-ketoglutarate (OKG), a nonessential amino acid produced in the body, is formed from a combination of two molecules of ornithine and one molecule of alpha-ketoglutarate (AKG), a glutamine precursor. Through a balanced and healthy diet, the body can produce sufficient supplies of OKG, although it is also taken as a dietary supplement.
OKG’s strong healing properties are beneficial in a number of treatments, including post-surgery, burns and malnourishment. OKG is effective in treating severe illness and injury due to its ability to block the catabolic effects of hormones that break down muscles and tissues while directly stimulating anabolic activity. Its role in helping to build up muscle has made it a popular sports supplement. Arginine and ornithine combined have also been found to improve muscle mass. In addition, OKG is known to regulate liver function and has shown promise in the treatment of hepatic encephalopathy, a liver cirrhosis.
Insufficient levels of OKG may result in immune and gastrointestinal dysfunctions, birth defects and delayed maturation. A number of conditions may arise that negatively affect the natural production of OKG, including rare genetic disorders and high stress and trauma conditions that impair the synthesis of OKG.
OKG can be obtained through high protein foods, including meats, dairy products, soybeans, white/wheat flour, gelatin, wheat, oats, coconuts, peanuts, walnuts, chocolate and carob.
It is recommended that OKG be taken in balance with other amino acids. For an adult, the daily required dosage is 5 to 10 grams. Doses higher than 10 grams daily may result in adverse reactions, such as nausea and abdominal cramps. The metabolism of amino acids may be improved by combining them with other nutrient supplements, such as B6, zinc, manganese and magnesium.
References:* “Donati L, Ziegler F, Pongelli G, et al. Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients. Clin Nutr. 1999;18:307–311
* “Czernichow B, Nsi-Emvo E, Galluser M, et al. Enteral supplementation with ornithine alpha ketoglutarate improves the early adaptive response to resection. Gut. 1997; 40:67-72
